Hi , we drove in May from Reggio di Calabria to Amalfi. Took us around 4,5 hrs hwy driving . Lots of construction but not too busy at that time. Now in the summer much more people travel by car so add extra time for that. We stopped in Tropea , great beaches, nice views . Did not take a ferry to Sicily but its very close . Check how much in advance you have to be at the ferry dock and if you can prebook your tickets ,especially if you are driving .
Good luck about 8 years ago